Imagine.
Incubate.
Ignite.
Advancing a New World of Clinical Research
i-Cubed™ is the center for clinical research innovation, powered by the unique expertise and resources of the Duke Clinical Research Institute. We support individuals, teams, and organizations in turning their ideas into tools, technologies, and processes that transform how clinical research is done — for the benefit of people everywhere.
If you have an idea or innovation that could solve a clinical research challenge, we want to work with you to:
Focus Areas
Research for all
Promoting equitable participation in research
Clinical research everywhere
Engaging communities beyond traditional research sites
Unleashing the power of all data
Moving beyond traditional data collection
New Tech Applications
Applying AI/ML and other new technologies to accelerate research
Simplifying the complex
Streamlining processes to speed discoveries
A Culture of Innovation
Here at i-Cubed, we believe in finding positive approaches to problem-solving. We weave that commitment into everything we do in our work together and with our external partners. You’ll see that in practice when you collaborate with i-Cubed.
News
- ExecRx Launches with Support from i-Cubed – Streamlining Medical Leadership for Healthcare and Research Companies January 13, 2025

ExecRx finds and places fractional medical leaders and advisors in roles that support organizations engaged in healthcare and research. The new company was incubated at i-Cubed, the center for clinical research innovation at the Duke Clinical Research Institute (DCRI).
ExecRx, so named for its prescriptive “right ...
- i-Cubed Helps KidsHeart App Expand Care for Infants with Congenital Heart Disease December 9, 2024

A new app that can revolutionize pediatric care for infants born with single-ventricle heart disease will soon have a larger reach thanks to support from i-Cubed, the center for clinical research innovation at the Duke Clinical Research Institute (DCRI).
Infants born with severe congenital heart defects such ...


